A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Yeah, I'm not quite sure what Y453F is about - might just be marginally beneficial.
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It appears sufficient times in mink to mean it must be selected for but possibly quite weakly. And possibly as a resultof the high density.
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Yup - plausibly this one becomes fixed when big populations get hit. A lot of diversity in the size of the various farms- especially in Denmark (not sure about NL - but I think they have more 'mega' farms).
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Here is a report I wrote for the WHO. To me the most interesting thing is the spike deletion at 69/70 that appears after Y453F and also appears after N469K in humans [shared file(s): Mink-associated_mutations_in_humans.pdf]
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2020-11-17 09:18
Andrew Rambaut
Note also the Utah human - also mink related, also 453F (slightly confidentially).
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One thing to be a data parasite (which implies some relationship to the host) and a data thug/thief.
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Thanks Andrew for sharing - very interested to get your insights into this. Will keep confidential - A LOT of disagreement in DK about how to handle that (most of those discussions driven by people that have no background in any of this...).
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We (WHO working group) did talk to the SSI but they were very cagy (as you might expect). But they sharing isolates now through the WHO I believe.
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FWIW - the 69/70 S deletion comes at a region that is disordered at least in some spike structures (reddish sphereshere). It's at the top of the spike but not close by to Y453 (bluish) so not obvious why the might be linked. Not likesubstructures that interact (for example the 6 helix bundles) where you expect compensatory/complementarymutations. [shared file(s): image.png]