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Slack / Private Message Drop, p.251 [SLACK_000465] · slack_pm:msg:02612

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Confidential but everyone is going bonkers at Denmark for not giving out any details.

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2020-11-05 14:05 Andrew Rambaut open

Y453F seems to have arisen 5 or 6 times in humans. But it arose 4 times independently in Marion's mink genomes and now in Denmark. Seems possible it is an adaptation to mink's ACE2 but also can occur in humans but not reallygo anywhere.
2020-11-05 14:11 Andrew Rambaut open

The variant that the Danes are going on their crazed furry creature killing spree about has 4 spike mutations - 69del,Y453F, I692V, M1229I
2020-11-05 14:13 Kristian G. Andersen open

Thanks Andrew - yeah, I noticed Y453F was found in NL as well. Is it public knowledge that these are the four mutations, or is that WHO confidential for now? I have a TON of DK reporters asking about this, but haven't found anything official.
2020-11-05 14:14 Kristian G. Andersen open

For this mink stuff - I could totally see selection in mink driving things like immune escape. Presumably selection for transmission (including longer infectious period) is high given that they're caged up.
2020-11-05 14:15 Andrew Rambaut

Confidential but everyone is going bonkers at Denmark for not giving out any details.
2020-11-05 14:16 Kristian G. Andersen open

So ridiculous - they have been sitting on a ton of mink+human sequencing data for months and nothing released. I'll call them out to a couple of journalists
2020-11-05 14:19 Andrew Rambaut open

They just dumped a whole lot of human data on GISAID but it is all from Apr/May not sure why they did that