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Slack / Private Message Drop, p.251 [SLACK_000465] · slack_pm:msg:02608

Date: 2020-11-05 14:05
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

Y453F seems to have arisen 5 or 6 times in humans. But it arose 4 times independently in Marion's mink genomes and now in Denmark. Seems possible it is an adaptation to mink's ACE2 but also can occur in humans but not reallygo anywhere.

In context

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2020-11-05 14:02 Kristian G. Andersen open

Not jealous :point_up_2: [shared file(s): kga.jpg]
2020-11-05 14:03 Kristian G. Andersen open

What else did I miss? Mink? Anything public on the specific mutations? I can see some of these have already been found in human cases, so unclear to me how we know they originated in mink?
2020-11-05 14:05 Andrew Rambaut

Y453F seems to have arisen 5 or 6 times in humans. But it arose 4 times independently in Marion's mink genomes and now in Denmark. Seems possible it is an adaptation to mink's ACE2 but also can occur in humans but not reallygo anywhere.
2020-11-05 14:11 Andrew Rambaut open

The variant that the Danes are going on their crazed furry creature killing spree about has 4 spike mutations - 69del,Y453F, I692V, M1229I
2020-11-05 14:13 Kristian G. Andersen open

Thanks Andrew - yeah, I noticed Y453F was found in NL as well. Is it public knowledge that these are the four mutations, or is that WHO confidential for now? I have a TON of DK reporters asking about this, but haven't found anything official.
2020-11-05 14:14 Kristian G. Andersen open

For this mink stuff - I could totally see selection in mink driving things like immune escape. Presumably selection for transmission (including longer infectious period) is high given that they're caged up.
2020-11-05 14:15 Andrew Rambaut open

Confidential but everyone is going bonkers at Denmark for not giving out any details.

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