Private channel session 539
9 messages over 16m, 2020-11-05 – 2020-11-05.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
-
Not jealous :point_up_2: [shared file(s): kga.jpg]
-
What else did I miss? Mink? Anything public on the specific mutations? I can see some of these have already been found in human cases, so unclear to me how we know they originated in mink?
-
Y453F seems to have arisen 5 or 6 times in humans. But it arose 4 times independently in Marion's mink genomes and now in Denmark. Seems possible it is an adaptation to mink's ACE2 but also can occur in humans but not reallygo anywhere.
-
The variant that the Danes are going on their crazed furry creature killing spree about has 4 spike mutations - 69del,Y453F, I692V, M1229I
-
Thanks Andrew - yeah, I noticed Y453F was found in NL as well. Is it public knowledge that these are the four mutations, or is that WHO confidential for now? I have a TON of DK reporters asking about this, but haven't found anything official.
-
For this mink stuff - I could totally see selection in mink driving things like immune escape. Presumably selection for transmission (including longer infectious period) is high given that they're caged up.
-
Confidential but everyone is going bonkers at Denmark for not giving out any details.
-
So ridiculous - they have been sitting on a ton of mink+human sequencing data for months and nothing released. I'll call them out to a couple of journalists
-
They just dumped a whole lot of human data on GISAID but it is all from Apr/May not sure why they did that