Chat message

Slack / Private Message Drop, p.251 [SLACK_000465] · slack_pm:msg:02609

Date: 2020-11-05 14:11
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

The variant that the Danes are going on their crazed furry creature killing spree about has 4 spike mutations - 69del,Y453F, I692V, M1229I

In context

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2020-11-05 14:02 Kristian G. Andersen open

Not jealous :point_up_2: [shared file(s): kga.jpg]
2020-11-05 14:03 Kristian G. Andersen open

What else did I miss? Mink? Anything public on the specific mutations? I can see some of these have already been found in human cases, so unclear to me how we know they originated in mink?
2020-11-05 14:05 Andrew Rambaut open

Y453F seems to have arisen 5 or 6 times in humans. But it arose 4 times independently in Marion's mink genomes and now in Denmark. Seems possible it is an adaptation to mink's ACE2 but also can occur in humans but not reallygo anywhere.
2020-11-05 14:11 Andrew Rambaut

The variant that the Danes are going on their crazed furry creature killing spree about has 4 spike mutations - 69del,Y453F, I692V, M1229I
2020-11-05 14:13 Kristian G. Andersen open

Thanks Andrew - yeah, I noticed Y453F was found in NL as well. Is it public knowledge that these are the four mutations, or is that WHO confidential for now? I have a TON of DK reporters asking about this, but haven't found anything official.
2020-11-05 14:14 Kristian G. Andersen open

For this mink stuff - I could totally see selection in mink driving things like immune escape. Presumably selection for transmission (including longer infectious period) is high given that they're caged up.
2020-11-05 14:15 Andrew Rambaut open

Confidential but everyone is going bonkers at Denmark for not giving out any details.
2020-11-05 14:16 Kristian G. Andersen open

So ridiculous - they have been sitting on a ton of mink+human sequencing data for months and nothing released. I'll call them out to a couple of journalists

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