Chat message

Slack / Private Message Drop, p.184 [SLACK_000398] · slack_pm:msg:01903

Date: 2020-09-18 17:14
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Furin cleavage site and molecular features Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

Here's what I have assembled so far - all look great. Only need to assemble one of the remaining pangolin CoVs, which has a huge dataset. RBD in green. Conclusion? Nothing to see here.... as expected. [shared file(s): MP789.jpg, P1E.jpg, P2S.jpg, P2V.jpg, P3B.jpg,P4L.jpg, P5E.jpg, P5L.jpg, RaTG13.jpg, RmYN02.jpg]

Extracted statements

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Statement	Grade	Attribution	Stance
Only need to assemble one of the remaining pangolin CoVs, which has a huge dataset.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

Only need to assemble one of the remaining pangolin CoVs, which has a huge dataset.

own voice, substantive

speaker_own

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-09-18 16:20 Kristian G. Andersen open

It's another bat CoV closely related (but not identical) to others previously sequenced. Every yellow bar is an intrahost variant >10% (SNPs are all linked as far as I can tell, so I think it's just one additional genome) [shared file(s): Screen Shot 2020-09-18 at 16.19.28.png]
2020-09-18 16:25 Edward C. Holmes open

Yes, I agree. I'll check back what we did - if anything - about this. It would be really interesting to see a phylogeny with that, RmYN02 and RmYN01 included.
2020-09-18 16:37 Kristian G. Andersen open

I'm just going to pull that minority genome out - I'll keep you posted... Yeah, this is very interesting
2020-09-18 16:39 Edward C. Holmes open

Great!
2020-09-18 17:14 Kristian G. Andersen

Here's what I have assembled so far - all look great. Only need to assemble one of the remaining pangolin CoVs, which has a huge dataset. RBD in green. Conclusion? Nothing to see here.... as expected. [shared file(s): MP789.jpg, P1E.jpg, P2S.jpg, P2V.jpg, P3B.jpg,P4L.jpg, P5E.jpg, P5L.jpg, RaTG13.jpg, RmYN02.jpg]
2020-09-18 17:40 Edward C. Holmes open

Great work! So annoying that these people are accusing of fabrication when they are honest scientists working hard. Makes by blood boil.
2020-09-18 18:03 Kristian G. Andersen open

Here's the minor genome - probably not a complete genome, but definitely present. [shared file(s): minor_variant_genome.fa]
2020-09-18 18:03 Kristian G. Andersen open

Alignment + tree [shared file(s): Alignment with minor RmYN02 RAxML Tree.nex, Alignment with minor RmYN02.nex]
2020-09-18 18:03 Edward C. Holmes open

Cool! Quick tree?

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