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Slack / Private Message Drop, p.85 [SLACK_000299] · slack_pm:msg:00863

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This is pretty interesting... [shared file(s): Screen Shot 2020-06-18 at 5.27.34 PM.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-06-18 16:36 Edward C. Holmes open

Had a quick look...if Alina is suggesting that the pangolin RBD came from humans she's totally mad (look at the synonymous diversity). 100% clear that that RBD is out there in nature. Not sure what hosts, but definitely in nature.
2020-06-18 16:42 Kristian G. Andersen open

Yeah, I'm not sure what she's suggesting... Either from human or somebody invented the sequence. Hasn't that sequence been seen from multiple animals by multiple labs?
2020-06-18 16:48 Edward C. Holmes open

Yes, it has. The two pangolin papers in Nature (different groups) both show the same RBD in the animals from Guangdong.
2020-06-18 16:58 Kristian G. Andersen open

Thought so...
2020-06-18 17:27 Kristian G. Andersen

This is pretty interesting... [shared file(s): Screen Shot 2020-06-18 at 5.27.34 PM.png]
2020-06-18 17:32 Edward C. Holmes open

But the pangolin sequence is only 'highly identical' at the amino acid level. Not synonymous sites...falls in the expected place at those sites.
2020-06-18 17:34 Kristian G. Andersen open

Yeah, agreed - but if what she's saying is actually true, then that's definitely strange - that is *not* how the authors describe their data and samples
2020-06-18 17:34 Kristian G. Andersen open

I'll get the manuscript from her
2020-06-18 17:37 Edward C. Holmes open

Let me see what I can do on this. I'm working with both groups.