Chat message

Slack / Private Message Drop, p.85 [SLACK_000299] · slack_pm:msg:00861

Date: 2020-06-18 16:48
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes
Topics: Furin cleavage site and molecular features Natural origin / zoonotic spillover

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Yes, it has. The two pangolin papers in Nature (different groups) both show the same RBD in the animals from Guangdong.

Extracted statements

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Statement	Grade	Attribution	Stance
The two pangolin papers in Nature (different groups) both show the same RBD in the animals from Guangdong.	own voice, substantive	speaker_own	asserts

Statement

Grade

Attribution

Stance

The two pangolin papers in Nature (different groups) both show the same RBD in the animals from Guangdong.

own voice, substantive

speaker_own

asserts

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-06-18 16:18 Kristian G. Andersen open

Speaking of animals and such - I don't know if some of you might want to chime in on this... https://twitter.com/Ayjchan/status/1273632816983683079?s=20
2020-06-18 16:30 Edward C. Holmes open

Not doing Twitter at the moment
2020-06-18 16:36 Edward C. Holmes open

Had a quick look...if Alina is suggesting that the pangolin RBD came from humans she's totally mad (look at the synonymous diversity). 100% clear that that RBD is out there in nature. Not sure what hosts, but definitely in nature.
2020-06-18 16:42 Kristian G. Andersen open

Yeah, I'm not sure what she's suggesting... Either from human or somebody invented the sequence. Hasn't that sequence been seen from multiple animals by multiple labs?
2020-06-18 16:48 Edward C. Holmes

Yes, it has. The two pangolin papers in Nature (different groups) both show the same RBD in the animals from Guangdong.
2020-06-18 16:58 Kristian G. Andersen open

Thought so...
2020-06-18 17:27 Kristian G. Andersen open

This is pretty interesting... [shared file(s): Screen Shot 2020-06-18 at 5.27.34 PM.png]
2020-06-18 17:32 Edward C. Holmes open

But the pangolin sequence is only 'highly identical' at the amino acid level. Not synonymous sites...falls in the expected place at those sites.
2020-06-18 17:34 Kristian G. Andersen open

Yeah, agreed - but if what she's saying is actually true, then that's definitely strange - that is *not* how the authors describe their data and samples