Slack / Private Message Drop — page 85

[2020-06-18 16:36:46] [Eddie Holmes] Had a quick look...if Alina is suggesting that the pangolin RBD came from humans she's totally mad (look at the synonymous diversity). 100% clear that that RBD is out there in nature. Not sure what hosts, but definitely in nature. [2020-06-18 16:42:14] [Kristian Andersen] Yeah, I'm not sure what she's suggesting... Either from human or somebody invented the sequence. Hasn't that sequence been seen from multiple animals by multiple labs? [2020-06-18 16:48:58] [Eddie Holmes] Yes, it has. The two pangolin papers in Nature (different groups) both show the same RBD in the animals from Guangdong. [2020-06-18 16:58:19] [Kristian Andersen] Thought so... [2020-06-18 17:27:54] [Kristian Andersen] This is pretty interesting... [shared file(s): Screen Shot 2020-06-18 at 5.27.34 PM.png] [2020-06-18 17:32:09] [Eddie Holmes] But the pangolin sequence is only 'highly identical' at the amino acid level. Not synonymous sites...falls in the expected place at those sites. [2020-06-18 17:34:36] [Kristian Andersen] Yeah, agreed - but if what she's saying is actually true, then that's definitely strange - that is *not* how the authors describe their data and samples [2020-06-18 17:34:56] [Kristian Andersen] I'll get the manuscript from her [2020-06-18 17:37:10] [Eddie Holmes] Let me see what I can do on this. I'm working with both groups. [2020-06-18 17:41:09] [Eddie Holmes] Still makes no sense because the Liu et al. paper come out before the pandemic. [2020-06-18 17:41:32] [Kristian Andersen] "Liu et al. paper come out before the pandemic" > Yup. [2020-06-18 17:42:11] [Eddie Holmes] Published online October 24th 2019 if I remember. [2020-06-18 17:43:29] [Kristian Andersen]