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Slack / Private Message Drop, p.57 [SLACK_000271] · slack_pm:msg:00573

Page text: p.57 · original PDF

Date
2020-06-06 03:29
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

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shared file(s): elife-58603-v1.pdf

In context

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  1. 2020-06-06 02:51 Robert F. Garry open
    "RTT plot for Ebola is super interesting" Agree - how do the RBDs align on the different branches?
  2. 2020-06-06 03:10 Edward C. Holmes open
    Got it. I don't suppose we know much about how ENaC- how looks in other species? Would be interesting to know what species OC43 and HKU1 originated in.
  3. 2020-06-06 03:20 Edward C. Holmes open
    Going through our scenarios, if true would the ENaC- + furin link argue for undetected circulation in humans? Possibly to get in animal passage? Could it explain why the furin site is sometimes lost in cell culture? It is clearly doing something. Bill's theory explains how it was created, but it would also be nice to understand how it ismaintained.
  4. 2020-06-06 03:28 Andrew Rambaut open
    Sorry - I am being dumb here. Can you layout exact what the proposed connection with ENaC- is?
  5. 2020-06-06 03:29 Edward C. Holmes
    shared file(s): elife-58603-v1.pdf
  6. 2020-06-06 03:29 Edward C. Holmes open
    Figure 1
  7. 2020-06-06 03:30 Andrew Rambaut open
    But not suggesting this was the source of the insertion recombination?
  8. 2020-06-06 03:30 Andrew Rambaut open
    Just why it might be doing in humans.
  9. 2020-06-06 03:31 Edward C. Holmes open
    No. But it explains why it is beneficial. A bit of undetected circulation in humans would solve a lot of problems.

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