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Slack / Private Message Drop, p.57 [SLACK_000271] · slack_pm:msg:00574

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Figure 1

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2020-06-06 03:10 Edward C. Holmes open

Got it. I don't suppose we know much about how ENaC- how looks in other species? Would be interesting to know what species OC43 and HKU1 originated in.
2020-06-06 03:20 Edward C. Holmes open

Going through our scenarios, if true would the ENaC- + furin link argue for undetected circulation in humans? Possibly to get in animal passage? Could it explain why the furin site is sometimes lost in cell culture? It is clearly doing something. Bill's theory explains how it was created, but it would also be nice to understand how it ismaintained.
2020-06-06 03:28 Andrew Rambaut open

Sorry - I am being dumb here. Can you layout exact what the proposed connection with ENaC- is?
2020-06-06 03:29 Edward C. Holmes open

shared file(s): elife-58603-v1.pdf
2020-06-06 03:29 Edward C. Holmes

Figure 1
2020-06-06 03:30 Andrew Rambaut open

But not suggesting this was the source of the insertion recombination?
2020-06-06 03:30 Andrew Rambaut open

Just why it might be doing in humans.
2020-06-06 03:31 Edward C. Holmes open

No. But it explains why it is beneficial. A bit of undetected circulation in humans would solve a lot of problems.
2020-06-06 03:37 Andrew Rambaut open

I see it now. Interesting.