Slack / Private Message Drop — page 104

Yeah, NIAID asked us about getting an isolate from a "mild infection"... Well, mild, severe, moderate, chances are they're all the same. I agree on getting something as basal on the tree as possible (that's assuming D614G _does not_ show resistance to neutralization - which is a real concern (e.g., GP A82V in Ebola does that). [2020-07-23 08:45:11] [Andrew Rambaut] Jeremy's preprint suggests it is sensitive to ABs [2020-07-23 08:45:39] [Andrew Rambaut] But I guess the point is it is the dominant form and will remain so. [2020-07-23 08:45:58] [Kristian Andersen] The UK has been playing hard and loose with viruses in the past, so I wouldn't be surprised if we'd see challenge trials from them. IMO, this virus is much too dangerous with too many uncertain long-term effects to deliberately infect people - especially given the HUGE number of cases we have in this country. [2020-07-23 08:46:42] [Kristian Andersen] Yeah, everything is basically D614G by now, so that's kinda the virus we need to make sure the vaccine works against - but I'm not really concerned there's a difference between Doug and Dougless here. [2020-07-23 08:47:02] [Andrew Rambaut] I agree that it is probably unnecessary - just try the vaccine. [2020-07-23 08:48:25] [Kristian Andersen] Let's just immunize Florida and see what happens.... :smiling_imp: [2020-07-23 08:51:01] [Robert Garry] I could get begind that [2020-07-23 08:51:23] [Robert Garry] but unfortunately it's not what they doinghttps://www.forbes.com/sites/brucejapsen/2020/06/02/fauci-modernas-phas e-3-covid-19-vaccine-trial-will-include-30000-young-and-old-individuals/#316e15174f75 [2020-07-23 08:52:55] [Kristian Andersen] I'm _super_ worried about Moderna... Just not convinced that thing is safe. [2020-07-23 08:53:03] [Robert Garry] Basically for Moderna they are immunizing/placeboing 30,000 people then sending them out to see how many get infected. [2020-07-23 08:53:53] [Kristian Andersen] They _really_ need to do that trial in high-transmission areas - i.e., not the North East! [2020-07-23 08:53:57] [Robert Garry] Agree - maybe not safe but even more dangerous - it may not work at all or very well - either would be a setback.