Chat message

Slack / Private Message Drop, p.104 [SLACK_000318] · slack_pm:msg:01054

Date: 2020-07-23 08:46
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Vaccines

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Yeah, everything is basically D614G by now, so that's kinda the virus we need to make sure the vaccine works against - but I'm not really concerned there's a difference between Doug and Dougless here.

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Statement	Grade	Attribution	Stance
Yeah, everything is basically D614G by now, so that's kinda the virus we need to make sure the vaccine works against - but I'm not really concerned there's a difference between Doug and Dougless here.	own voice, substantive	speaker_own	instructs

Statement

Grade

Attribution

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own voice, substantive

speaker_own

instructs

In context

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2020-07-23 08:44 Kristian G. Andersen open

Yeah, NIAID asked us about getting an isolate from a "mild infection"... Well, mild, severe, moderate, chances are they're all the same. I agree on getting something as basal on the tree as possible (that's assuming D614G _does not_ show resistance to neutralization - which is a real concern (e.g., GP A82V in Ebola does that).
2020-07-23 08:45 Andrew Rambaut open

Jeremy's preprint suggests it is sensitive to ABs
2020-07-23 08:45 Andrew Rambaut open

But I guess the point is it is the dominant form and will remain so.
2020-07-23 08:45 Kristian G. Andersen open

The UK has been playing hard and loose with viruses in the past, so I wouldn't be surprised if we'd see challenge trials from them. IMO, this virus is much too dangerous with too many uncertain long-term effects to deliberately infect people - especially given the HUGE number of cases we have in this country.
2020-07-23 08:46 Kristian G. Andersen

Yeah, everything is basically D614G by now, so that's kinda the virus we need to make sure the vaccine works against - but I'm not really concerned there's a difference between Doug and Dougless here.
2020-07-23 08:47 Andrew Rambaut open

I agree that it is probably unnecessary - just try the vaccine.
2020-07-23 08:48 Kristian G. Andersen open

Let's just immunize Florida and see what happens.... :smiling_imp:
2020-07-23 08:51 Robert F. Garry open

I could get begind that
2020-07-23 08:51 Robert F. Garry open

but unfortunately it's not what they doinghttps://www.forbes.com/sites/brucejapsen/2020/06/02/fauci-modernas-phase-3-covid-19-vaccine-trial-will-include-30000-young-and-old-individuals/#316e15174f75

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