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Slack / Private Message Drop, p.1028 [SLACK_001242] · slack_pm:msg:10749

Page text: p.1028 · original PDF

Date
2021-11-25 07:07
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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Bob - do we know anything about NSP4? B.1.1.529 is sharing T492I with an extremely rapidly growing lineage in Chile (although I suspect that must almost certainly be doing to epi factors, not that particular mutation, but :man-shrugging:): https://outbreak.info/situation-reports?pango&muts=ORf1b%3AT2163I&selected=CHL &loc=USA&loc=USA_US-CA&loc=CHL&overlay=false

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  1. 2021-11-25 05:51 Andrew Rambaut open
    B.1.1.529 is looking bad. Probably widely prevalent in RSA, 2 new cases in Hong Kong (no mention of travel this time)
  2. 2021-11-25 05:51 Andrew Rambaut open
    https://www.youtube.com/watch?v=Vh4XMueP1zQ
  3. 2021-11-25 06:35 Kristian G. Andersen open
    Any summary of the video or time stamp to go to?
  4. 2021-11-25 07:07 Kristian G. Andersen
    Bob - do we know anything about NSP4? B.1.1.529 is sharing T492I with an extremely rapidly growing lineage in Chile (although I suspect that must almost certainly be doing to epi factors, not that particular mutation, but :man-shrugging:): https://outbreak.info/situation-reports?pango&muts=ORf1b%3AT2163I&selected=CHL &loc=USA&loc=USA_US-CA&loc=CHL&overlay=false
  5. 2021-11-25 07:32 Andrew Rambaut open
    Tulio starts at 26 mins
  6. 2021-11-25 08:13 Robert F. Garry open
    It's involved in remodeling the internal membranes - that where the transcription/replication takes place. [shared file(s): image.png]
  7. 2021-11-25 08:16 Andrew Rambaut open
    This evening I think we may be back to square one with respect to vaccination and prior immunity. New pandemic anyone?
  8. 2021-11-25 08:22 Robert F. Garry open
    I can model it - not possible to get a structure. It has probably 5 TM domains, which you expect of a membrane remodeler. The TMpred prediction is underlined and I bolded the "by-eye" most likely TMs. There are three internal domains that are in blue and italicized. There is a large external domain that has several cysteines -dicysteines - it'san uneven number so maybe a metal binding spot. The third external domain has a lot of aromatic amino acids - sodoes the putative fifth TM domain so that's probably the business part of the membrane remodeling. The T492Imutation is shown - it's at the end of the molecule - inside - 4 cysteines that domain could be regulatory.

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