Private channel session 1656
8 messages over 2h 31m, 2021-11-25 – 2021-11-25.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
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B.1.1.529 is looking bad. Probably widely prevalent in RSA, 2 new cases in Hong Kong (no mention of travel this time)
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https://www.youtube.com/watch?v=Vh4XMueP1zQ
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Any summary of the video or time stamp to go to?
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Bob - do we know anything about NSP4? B.1.1.529 is sharing T492I with an extremely rapidly growing lineage in Chile (although I suspect that must almost certainly be doing to epi factors, not that particular mutation, but :man-shrugging:): https://outbreak.info/situation-reports?pango&muts=ORf1b%3AT2163I&selected=CHL &loc=USA&loc=USA_US-CA&loc=CHL&overlay=false
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Tulio starts at 26 mins
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It's involved in remodeling the internal membranes - that where the transcription/replication takes place. [shared file(s): image.png]
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This evening I think we may be back to square one with respect to vaccination and prior immunity. New pandemic anyone?
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I can model it - not possible to get a structure. It has probably 5 TM domains, which you expect of a membrane remodeler. The TMpred prediction is underlined and I bolded the "by-eye" most likely TMs. There are three internal domains that are in blue and italicized. There is a large external domain that has several cysteines -dicysteines - it'san uneven number so maybe a metal binding spot. The third external domain has a lot of aromatic amino acids - sodoes the putative fifth TM domain so that's probably the business part of the membrane remodeling. The T492Imutation is shown - it's at the end of the molecule - inside - 4 cysteines that domain could be regulatory.