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Slack / Private Message Drop, p.1027 [SLACK_001241] · slack_pm:msg:10738

Page text: p.1027 · original PDF

Date
2021-11-24 09:24
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

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The insertion ("TAGTGCGTGAGCCAGAA") around 630 could be interesting - obviously a short sequence, but it ain't from SC2 itself and the top BLAST results match fungi, cholera, and a fish...

In context

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  1. 2021-11-24 09:11 Kristian G. Andersen open
    What the heck is up here - Hu1 on top, Botswana at the bottom [shared file(s): Screen Shot 2021-11-24 at 9.07.10AM.png]
  2. 2021-11-24 09:12 Kristian G. Andersen open
    In AA space: [shared file(s): Screen Shot 2021-11-24 at 9.07.32 AM.png]
  3. 2021-11-24 09:13 Kristian G. Andersen open
    Here's the key part of the RBD - contact residues listed in purple above. This makes me believe this could be evolution in a non-human host, so I'll have to change my 70/30 odds to 50/50 based on this alone. This is very interesting. [shared file(s): Screen Shot 2021-11-24 at 9.08.55 AM.png]
  4. 2021-11-24 09:24 Robert F. Garry open
    Agree - it's freaky!
  5. 2021-11-24 09:24 Kristian G. Andersen
    The insertion ("TAGTGCGTGAGCCAGAA") around 630 could be interesting - obviously a short sequence, but it ain't from SC2 itself and the top BLAST results match fungi, cholera, and a fish...
  6. 2021-11-24 09:26 Robert F. Garry open
    THis insertions are rare - wasn't there a preprint or virological post on those a while back?
  7. 2021-11-24 09:27 Kristian G. Andersen open
    Yeah - same Tom: https://virological.org/t/putative-host-origins-of-rna-insertions-in-sars-cov-2-genomes/761
  8. 2021-11-24 09:33 Robert F. Garry open
    @Andrew Rambaut But saying it out loud only can get you in deep trouble.
  9. 2021-11-24 09:37 Andrew Rambaut open
    Yes - Tom has identified that insertion in a human mRNA

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