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Slack / Private Message Drop, p.1028 [SLACK_001242] · slack_pm:msg:10740

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Yeah - same Tom: https://virological.org/t/putative-host-origins-of-rna-insertions-in-sars-cov-2-genomes/761

Links shared

preprint https://virological.org/t/putative-host-origins-of-rna-insertions-in-sars-cov-2-genomes/761

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-11-24 09:13 Kristian G. Andersen open

Here's the key part of the RBD - contact residues listed in purple above. This makes me believe this could be evolution in a non-human host, so I'll have to change my 70/30 odds to 50/50 based on this alone. This is very interesting. [shared file(s): Screen Shot 2021-11-24 at 9.08.55 AM.png]
2021-11-24 09:24 Robert F. Garry open

Agree - it's freaky!
2021-11-24 09:24 Kristian G. Andersen open

The insertion ("TAGTGCGTGAGCCAGAA") around 630 could be interesting - obviously a short sequence, but it ain't from SC2 itself and the top BLAST results match fungi, cholera, and a fish...
2021-11-24 09:26 Robert F. Garry open

THis insertions are rare - wasn't there a preprint or virological post on those a while back?
2021-11-24 09:27 Kristian G. Andersen

Yeah - same Tom: https://virological.org/t/putative-host-origins-of-rna-insertions-in-sars-cov-2-genomes/761
2021-11-24 09:33 Robert F. Garry open

@Andrew Rambaut But saying it out loud only can get you in deep trouble.
2021-11-24 09:37 Andrew Rambaut open

Yes - Tom has identified that insertion in a human mRNA
2021-11-24 09:37 Andrew Rambaut open

Somewhere on twitter