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Slack / Private Message Drop, p.1007 [SLACK_001221] · slack_pm:msg:10508

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(pangolins also don't have that ACE2 glycan...)

Extracted statements

Rule-extracted, not adjudicated. The grade says what may be done with each one; read the document above before relying on any of them.

Statement	Grade	Attribution	Stance
(pangolins also don't have that ACE2 glycan...)	needs context	speaker_own	asserts

Statement

Grade

Attribution

Stance

(pangolins also don't have that ACE2 glycan...)

needs context

speaker_own

asserts

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-09-24 15:00 Robert F. Garry open

SC1 has a glycan at 109 that is in the other bat Covs except for RaTG13 and Laos bat 52. It also missing in SC2 spike.
2021-09-24 15:07 Kristian G. Andersen open

I'm looking closely at N357 (SC1 coordinates), which is the one SC2 looses (N370 in SC2 coordinates). The glycanat N357 interacts with the N322 glycan on ACE2. What's interesting here - Rhinolophus macrotis _does_ _not_ haveN322, unlike most other bats and instead has K322. Now, does the missing N357 glycan in SC2 mean it can livehappily in Rhinolophus macrotis?Maybe: https://pubmed.ncbi.nlm.nih.gov/34018203/
2021-09-24 15:10 Kristian G. Andersen

(pangolins also don't have that ACE2 glycan...)
2021-09-24 15:34 Edward C. Holmes open

Interesting observation. R. macrotis has a wide geographic range.