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Slack / Private Message Drop, pp.819-820 [SLACK_001033] · slack_pm:msg:08549

Date: 2021-05-16 06:55
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Agreed, this is key. However, they'll counter - "yes, but they have previously managed to identify and culture bat viruses that bind to human ACE2" SLACK_001034

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2021-05-16 06:55 Kristian G. Andersen

Agreed, this is key. However, they'll counter - "yes, but they have previously managed to identify and culture bat viruses that bind to human ACE2" SLACK_001034
2021-05-16 06:55 Kristian G. Andersen open

Obviously not the same thing, but let's keep fleshing out this particular argument as it is indeed key - just need to becareful we don't end up in a trap.
2021-05-16 06:55 Robert F. Garry open

All this is great work - asec just finished doctorate in nursing at Hopkins - came in and we had a bit of a celebration. Will add what I can.. I G is working on his own response to the Bloomshitters that he will post on virological (makes/corrects a few points in my multi-market post - i've seen a draft and it's as you might guess really well written in his expository way.
2021-05-16 06:55 Robert F. Garry open

https//www.ncbi.nim.nih.gov/pmc/articles/PMC5309958/ This little paper from @Eddie Holmes and references therein is highly relevant to the hku-1 analogy, which is spot-on.
2021-05-16 06:55 Robert F. Garry open

OC43 is relevant- worth remembering that NL63 and HKU-1 were discovered after SC1 and as a result of virus hunting driven by SC1. https://www.ncbi.nim.nih.gov/pmc/articles/PMC3194943/ "Before the SARS epidemic in 2003, there were only 19 known coronaviruses, including 2 human, 13 mammalian, and 4 avian coronaviruses. After the SARS epidemic, more than 20 additional novel coronaviruses have been described with complete genome sequences (9, 24-26, 31, 42, 45, 50, 53, 54, 57). These include 3 human coronaviruses, 15 mammalian coronaviruses, and 4 avian coronaviruses. For human coronaviruses, human coronavirus NL63 (HCoV-NL63) (an alphacoronavirus) and human coronavirus HKU1 (HCoV-HKU1) (a betacoronavirus) have been discovered in addition to the two previously known human coronaviruses, human coronavirus 229E (HCoV-229E) (an alphacoronavirus) and human coronavirus OC43 (HCoV-OC43) (a betacoronavirus), as well as SARS-CoV (a betacoronavirus) (9, 45, 53, 56)"

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