A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Agreed, this is key. However, they'll counter - "yes, but they have previously managed to identify and culture bat viruses that bind to human ACE2" SLACK_001034
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2021-05-16 06:55
Kristian G. Andersen
Obviously not the same thing, but let's keep fleshing out this particular argument as it is indeed key - just need to becareful we don't end up in a trap.
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All this is great work - asec just finished doctorate in nursing at Hopkins - came in and we had a bit of a celebration. Will add what I can.. I G is working on his own response to the Bloomshitters that he will post on virological (makes/corrects a few points in my multi-market post - i've seen a draft and it's as you might guess really well written in his expository way.
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https//www.ncbi.nim.nih.gov/pmc/articles/PMC5309958/ This little paper from @Eddie Holmes and references therein is highly relevant to the hku-1 analogy, which is spot-on.
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OC43 is relevant- worth remembering that NL63 and HKU-1 were discovered after SC1 and as a result of virus hunting driven by SC1. https://www.ncbi.nim.nih.gov/pmc/articles/PMC3194943/ "Before the SARS epidemic in 2003, there were only 19 known coronaviruses, including 2 human, 13 mammalian, and 4 avian coronaviruses. After the SARS epidemic, more than 20 additional novel coronaviruses have been described with complete genome sequences (9, 24-26, 31, 42, 45, 50, 53, 54, 57). These include 3 human coronaviruses, 15 mammalian coronaviruses, and 4 avian coronaviruses. For human coronaviruses, human coronavirus NL63 (HCoV-NL63) (an alphacoronavirus) and human coronavirus HKU1 (HCoV-HKU1) (a betacoronavirus) have been discovered in addition to the two previously known human coronaviruses, human coronavirus 229E (HCoV-229E) (an alphacoronavirus) and human coronavirus OC43 (HCoV-OC43) (a betacoronavirus), as well as SARS-CoV (a betacoronavirus) (9, 45, 53, 56)"
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https://pubmed.ncbi.nlm.nih.gov/29551 135/" *HCoV-OC43 is thought to have emerged from ancestors in domestic animals such as cattle or swine.* The bovine coronavirus has been suggested to be a possible ancestor, from whichHCoV-OC43 may have emerged in the context of a *pandemic recorded historically at the end of the 19th century*. New data suggest that HCoV-229E may actually be transferred from dromedary camels similar to Middle East respiratory syndrome (MERS) coronavirus. This scenario provides important ecological parallels to the presentprepandemic pattern of host associations of the MERS coronavirus."