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Slack / Private Message Drop, p.768 [SLACK_000982] · slack_pm:msg:08039

Page text: p.768 · original PDF

Date
2021-05-10 09:10
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut
Topics
Wuhan Institute of Virology collaboration

Recipients on this medium are inferred from channel membership, not per-message addressing.

I forgot to add in p(f) = probability that WIV is fibbing

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StatementGradeAttributionStance
I forgot to add in p(f) = probability that WIV is fibbing needs context speaker_own asserts

In context

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  1. 2021-05-10 08:37 Andrew Rambaut open
    If you have zero evidence that SC2 was in the lab then you are left with this vanishingly small prior probability.
  2. 2021-05-10 08:44 Robert F. Garry open
    ? [shared file(s): image.png]
  3. 2021-05-10 08:54 Andrew Rambaut open
    t proportion of bat viruses that are carnivore/human transmissible e number of exposures between bats and carnivores (over all locations, and over decades) p(h) probability of human infection per carnivore outbreak p(p) probability of pandemic arising per human infection p_zoonotic = t x e x p(h) x p(p) t is very small but e is very large For the lab scenario N = number of samples collected by the lab p(i) = probability a sample remains infectious p(l) = probability of a lab infection s = number of scientists handling material p_lab = t x N x p(i) x (1 - [1 - p(l)] ^ s) x p(p) In this one, t is very small, all of the p() are < 1 and N is not that big
  4. 2021-05-10 09:05 Robert F. Garry open
    Brilliant! Math>>>Figure
  5. 2021-05-10 09:10 Andrew Rambaut
    I forgot to add in p(f) = probability that WIV is fibbing
  6. 2021-05-10 09:12 Kristian G. Andersen open
    Love it @Andrew Rambaut - and yes, this is what we need. For the ones above e >>> N and p(i) is also very low - probably ~1%. p(l) can be calibrated based on previous lab escapes and is also low - much less than 1%, but let's keep it at that. p(h) we can calibrate based on sero surveys, using a one year seroreversion - so 2% ofpopulation in certain areas.
  7. 2021-05-10 09:12 Kristian G. Andersen open
    According to The Seeker, nobody in their right mind would consider p(f) > 0.... :wink:
  8. 2021-05-10 09:13 Kristian G. Andersen open
    Worth plotting some of this out?
  9. 2021-05-10 09:13 Andrew Rambaut open
    p(h) may be close to 1 - if there is an outbreak in a farmed carnivore population.

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