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Slack / Private Message Drop, p.734 [SLACK_000948] · slack_pm:msg:07683

Page text: p.734 · original PDF

Date: 2021-04-28 06:55
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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Perhaps Sputnik V will just spread round the world of its own accord?

In context

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2021-04-28 05:07 Robert F. Garry open

https://thenationalpulse.com/news/scientists-debunking-lab-leak-theory-linked-to-ccp/
2021-04-28 06:02 Edward C. Holmes open

I was invited to that meeting. Bloody glad I didn't go.
2021-04-28 06:51 Andrew Rambaut open

Seen this one? Nelly, Pooh and Eek (plus a mutation at 144) https://github.com/cov-lineages/pango-designation/issues/57
2021-04-28 06:55 Andrew Rambaut open

'neglected' - https://twitter.com/angie_rasmussen/status/1387397186372005893
2021-04-28 06:55 Andrew Rambaut

Perhaps Sputnik V will just spread round the world of its own accord?
2021-04-28 06:56 Kristian G. Andersen open

Wait, what????
2021-04-28 07:00 Kristian G. Andersen open

@Andrew Rambaut - here's the B.1 lineage. A few in the US: https://outbreak.info/situation-reports?pango=B.1&am p;muts=S%3AN501Y&muts=S%3AE484K&mut[...]AR346K&muts=S%3AP681H&loc=USA&am p;loc=USA_US-CA&selected=Worldwide
2021-04-28 07:00 Robert F. Garry open

```1 msdngpqnqr napritfggp sdstgsnqng ersgarskqr rpqglpnnta swftaltqhg 61 kedlkfprgq gvpintnssp ddqigyyrra trrirggdgk mkdlsprwyf yylgtgpeag 121 lpygankygi iwvategaln tpkdhigtrn pannaaivlq lpqgttlpkg fyaegsrggs 181 qassrsssrs rnssrnstpg ssRGTsparm agnggdaala lllldrlnql eskisgkgqq 241 qqgqtvtkks aaeaskkprq krtatkaynv tqafgrrgpe qtqgnfgdqe lirqgtdykh 301 wpqiaqfaps asaffgmsri gmevtpsgtw ltytgaikld dkdpnfkdqv illnkhiday 361 ktfpptepkk dkkkkadetq alpqrqkkqq tvtllpaadl ddfskqlqqs mssadstqa``` Nucleocapsid sequence. Like Lassa N and several other RNA virus nucleoproteins there is a 2-domain structure. The N-term domain binds RNA. The C-term domain mediates dimerization. In btwn the two domains is a linker. In SC2 the linker is arginine serine (RS) rich. It is "intrinsically disordered" and therefore does not show up in the X-rayor cryo structures. 203-205 sequence RGT is near the end of the linker. The linker is highly phosphorylated -therefore probably regulates N function - the mutations could impact those functions which could affect assembly, virus load or virus distribution etc and yes this will impact transmissibility.
2021-04-28 07:01 Andrew Rambaut open

@Kristian Andersen I think this one is interesting because it has almost nothing else other than Phil and Doug from before and then the 4 spike mutations

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