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Slack / Private Message Drop, p.734 [SLACK_000948] · slack_pm:msg:07682

Page text: p.734 · original PDF

Date
2021-04-28 06:55
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker
Andrew Rambaut

Recipients on this medium are inferred from channel membership, not per-message addressing.

'neglected' - https://twitter.com/angie_rasmussen/status/1387397186372005893

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  1. 2021-04-28 05:05 Robert F. Garry open
    PooH or PooR both bad - would be very surprised if both don't enhance cleavage R>H probably.
  2. 2021-04-28 05:07 Robert F. Garry open
    https://thenationalpulse.com/news/scientists-debunking-lab-leak-theory-linked-to-ccp/
  3. 2021-04-28 06:02 Edward C. Holmes open
    I was invited to that meeting. Bloody glad I didn't go.
  4. 2021-04-28 06:51 Andrew Rambaut open
    Seen this one? Nelly, Pooh and Eek (plus a mutation at 144) https://github.com/cov-lineages/pango-designation/issues/57
  5. 2021-04-28 06:55 Andrew Rambaut
    'neglected' - https://twitter.com/angie_rasmussen/status/1387397186372005893
  6. 2021-04-28 06:55 Andrew Rambaut open
    Perhaps Sputnik V will just spread round the world of its own accord?
  7. 2021-04-28 06:56 Kristian G. Andersen open
    Wait, what????
  8. 2021-04-28 07:00 Kristian G. Andersen open
    @Andrew Rambaut - here's the B.1 lineage. A few in the US: https://outbreak.info/situation-reports?pango=B.1&am p;muts=S%3AN501Y&muts=S%3AE484K&mut[...]AR346K&muts=S%3AP681H&loc=USA&am p;loc=USA_US-CA&selected=Worldwide
  9. 2021-04-28 07:00 Robert F. Garry open
    ```1 msdngpqnqr napritfggp sdstgsnqng ersgarskqr rpqglpnnta swftaltqhg 61 kedlkfprgq gvpintnssp ddqigyyrra trrirggdgk mkdlsprwyf yylgtgpeag 121 lpygankygi iwvategaln tpkdhigtrn pannaaivlq lpqgttlpkg fyaegsrggs 181 qassrsssrs rnssrnstpg ssRGTsparm agnggdaala lllldrlnql eskisgkgqq 241 qqgqtvtkks aaeaskkprq krtatkaynv tqafgrrgpe qtqgnfgdqe lirqgtdykh 301 wpqiaqfaps asaffgmsri gmevtpsgtw ltytgaikld dkdpnfkdqv illnkhiday 361 ktfpptepkk dkkkkadetq alpqrqkkqq tvtllpaadl ddfskqlqqs mssadstqa``` Nucleocapsid sequence. Like Lassa N and several other RNA virus nucleoproteins there is a 2-domain structure. The N-term domain binds RNA. The C-term domain mediates dimerization. In btwn the two domains is a linker. In SC2 the linker is arginine serine (RS) rich. It is "intrinsically disordered" and therefore does not show up in the X-rayor cryo structures. 203-205 sequence RGT is near the end of the linker. The linker is highly phosphorylated -therefore probably regulates N function - the mutations could impact those functions which could affect assembly, virus load or virus distribution etc and yes this will impact transmissibility.

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