Private channel session 1296
23 messages over 2h 57m, 2021-04-28 – 2021-04-28.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
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Atlantic article - could have been worse - at least no mention of GVP.
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Farming the mink, raccoon dogs, etc, etc, etc - so many opportunities for spillover. Follow the animals...
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I agree, Kristian, with Pooh being involved in the transmissibility - have thought it from the beginning - too much of acoincidence that B.1.1.7 had a FCS mutation (back when it was very rare). Now with all the other 681 mutations coming up (and 677 possibly). Certainly looks like B.1.351 is not as transmissible as B.1.1.7 and probably not P.1 either - they have not invadedinto new areas in the same way. We are looking at whether the FCS mutations are cropping up / spreading inpopulations with moderate NPI (i.e., like the English November lock-down where schools were still open etc). Total lock down clearly works against B.1.1.7 as much as any and it is possible that no-NPI doesn't really benefit B.1.1.7because it has a shorter (but stronger and earlier) infectious period.
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:clown_face: on :clown_face: Billy aka Kevin - on to something? [shared file(s): image.png]
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PooH or PooR both bad - would be very surprised if both don't enhance cleavage R>H probably.
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https://thenationalpulse.com/news/scientists-debunking-lab-leak-theory-linked-to-ccp/
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I was invited to that meeting. Bloody glad I didn't go.
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Seen this one? Nelly, Pooh and Eek (plus a mutation at 144) https://github.com/cov-lineages/pango-designation/issues/57
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'neglected' - https://twitter.com/angie_rasmussen/status/1387397186372005893
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Perhaps Sputnik V will just spread round the world of its own accord?
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Wait, what????
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@Andrew Rambaut - here's the B.1 lineage. A few in the US: https://outbreak.info/situation-reports?pango=B.1&am p;muts=S%3AN501Y&muts=S%3AE484K&mut[...]AR346K&muts=S%3AP681H&loc=USA&am p;loc=USA_US-CA&selected=Worldwide
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```1 msdngpqnqr napritfggp sdstgsnqng ersgarskqr rpqglpnnta swftaltqhg 61 kedlkfprgq gvpintnssp ddqigyyrra trrirggdgk mkdlsprwyf yylgtgpeag 121 lpygankygi iwvategaln tpkdhigtrn pannaaivlq lpqgttlpkg fyaegsrggs 181 qassrsssrs rnssrnstpg ssRGTsparm agnggdaala lllldrlnql eskisgkgqq 241 qqgqtvtkks aaeaskkprq krtatkaynv tqafgrrgpe qtqgnfgdqe lirqgtdykh 301 wpqiaqfaps asaffgmsri gmevtpsgtw ltytgaikld dkdpnfkdqv illnkhiday 361 ktfpptepkk dkkkkadetq alpqrqkkqq tvtllpaadl ddfskqlqqs mssadstqa``` Nucleocapsid sequence. Like Lassa N and several other RNA virus nucleoproteins there is a 2-domain structure. The N-term domain binds RNA. The C-term domain mediates dimerization. In btwn the two domains is a linker. In SC2 the linker is arginine serine (RS) rich. It is "intrinsically disordered" and therefore does not show up in the X-rayor cryo structures. 203-205 sequence RGT is near the end of the linker. The linker is highly phosphorylated -therefore probably regulates N function - the mutations could impact those functions which could affect assembly, virus load or virus distribution etc and yes this will impact transmissibility.
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@Kristian Andersen I think this one is interesting because it has almost nothing else other than Phil and Doug from before and then the 4 spike mutations
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@Kristian Andersen It is like a really pure constellation.
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@Kristian Andersen Agreed. We have started seeing a lot of B.1, so we'll be on the lookout.
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That Sputnik V stuff is crazy AF. I wonder if the Ad26 is competent too? Ad5 is pretty prevalent, so while certainly aproblem, less so. Ad26 on the other hand...
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more grist for the anti-vaxxers and other opportunists
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"Perhaps Sputnik V will just spread round the world of its own accord?" NOT a bad idea - in an evil/not evil mad scientist kind of way.
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Yeah - it is obviously one way of manufacturing vaccine.
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Might accelerate vaccination efforts in hard-to-reach areas... Good plan, Russia.
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Do you think Russia are just going for the win on number of vaccinations?
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Clearly. It's going to be hard to track, although they could have created an epitope for MADE-IN-RUSSIA so we can keep tally via ELISA.