Slack / Private Message Drop — page 734

into new areas in the same way. We are looking at whether the FCS mutations are cropping up / spreading in populations with moderate NPI (i.e., like the English November lock-down where schools were still open etc). Total lock down clearly works against B.1.1.7 as much as any and it is possible that no-NPI doesn't really benefit B.1.1.7 because it has a shorter (but stronger and earlier) infectious period. [2021-04-28 05:03:02] [Robert Garry] :clown_face: on :clown_face: Billy aka Kevin - on to something? [shared file(s): image.png] [2021-04-28 05:05:05] [Robert Garry] PooH or PooR both bad - would be very surprised if both don't enhance cleavage R>H probably. [2021-04-28 05:07:46] [Robert Garry] https://thenationalpulse.com/news/scientists-debunking-lab-leak-theory-linked-to-ccp/ [2021-04-28 06:02:51] [Eddie Holmes] I was invited to that meeting. Bloody glad I didn't go. [2021-04-28 06:51:44] [Andrew Rambaut] Seen this one? Nelly, Pooh and Eek (plus a mutation at 144) https://github.com/cov-lineages/pango-designation/issues/57 [2021-04-28 06:55:20] [Andrew Rambaut] 'neglected' - https://twitter.com/angie_rasmussen/status/1387397186372005893 [2021-04-28 06:55:52] [Andrew Rambaut] Perhaps Sputnik V will just spread round the world of its own accord? [2021-04-28 06:56:25] [Kristian Andersen] Wait, what???? [2021-04-28 07:00:05] [Kristian Andersen] [thread - ID: 2021-04-28 07:00:05] @Andrew Rambaut - here's the B.1 lineage. A few in the US: https://outbreak.info/situation-reports?pango=B.1&am p;muts=S%3AN501Y&muts=S%3AE484K&mut[...]AR346K&muts=S%3AP681H&loc=USA&am p;loc=USA_US-CA&selected=Worldwide [2021-04-28 07:00:19] [Robert Garry] ```1 msdngpqnqr napritfggp sdstgsnqng ersgarskqr rpqglpnnta swftaltqhg 61 kedlkfprgq gvpintnssp ddqigyyrra trrirggdgk mkdlsprwyf yylgtgpeag 121 lpygankygi iwvategaln tpkdhigtrn pannaaivlq lpqgttlpkg fyaegsrggs 181 qassrsssrs rnssrnstpg ssRGTsparm agnggdaala lllldrlnql eskisgkgqq 241 qqgqtvtkks aaeaskkprq krtatkaynv tqafgrrgpe qtqgnfgdqe lirqgtdykh 301 wpqiaqfaps asaffgmsri gmevtpsgtw ltytgaikld dkdpnfkdqv illnkhiday 361 ktfpptepkk dkkkkadetq alpqrqkkqq tvtllpaadl ddfskqlqqs mssadstqa``` Nucleocapsid sequence. Like Lassa N and several other RNA virus nucleoproteins there is a 2-domain structure.