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Slack / Private Message Drop, p.731 [SLACK_000945] · slack_pm:msg:07665

Page text: p.731 · original PDF

Date: 2021-04-27 18:47
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Interferon?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-04-27 18:44 Kristian G. Andersen open

Are we starting to think maybe P681H/R could be a bad boy? Looking at the most recent variants, assuming B.1.617might plausibly be both more transmissible and escape some level of immunity, the latter comes down to L452R and the NTD, while the former may be linked to P681R (it doesn't have N501Y).P681H/R absent from both P.1 and B.1.351 (I'm getting increasingly more convinced 351 isn't more transmissible, but I'm less sure about P.1). [shared file(s): Screen Shot 2021-04-27 at 6.42.05 PM.png]
2021-04-27 18:45 Kristian G. Andersen open

If looking outside the spike, what do we know about N? An interest pattern around position 203/204/205 here [shared file(s): Screen Shot 2021-04-27 at 6.39.40 PM.png]
2021-04-27 18:46 Kristian G. Andersen open

Could N be involved in transmissibility? Live link here: https://outbreak.info/compare-lineages?pango=B.1.1.7&pango=B.1.351&pango=P.1& pango=[...]gene=ORF7a&gene=ORF7b&gene=ORF8&gene=N&gene=ORF10&threshold=
2021-04-27 18:47 Kristian G. Andersen

Interferon?
2021-04-27 19:18 Edward C. Holmes open

I had at chat with the genomics people here yesterday and they said that most of the people who are coming into our hotel quarantine system from India have B.1.1.7. Apparently 20% on one flight were infected.
2021-04-27 19:19 Robert F. Garry open

"Could N be involved in transmissibility?" yes - I'll take a look.
2021-04-27 19:40 Kristian G. Andersen open

20%... I think we see an example of what can happen if you give B.1.1.7 (and possibly 617) free reign. Pure devastation - the reports are terrifying.
2021-04-27 20:30 Kristian G. Andersen open

So much bs in this one. Phase I and II trials for vaccines against novel viruses we don't know anything about? Other than, of course, they're the most likely ones to case future pandemics. Suuuuuure._"Step two is something like Operation Warp Speed for the pandemics of the future. Once scientists have the resources to identify and track viruses with the gravest pandemic potential, a consortium of countries led by the U.S.should fund Phase 1 and Phase 2 trials around the world to test new vaccines against them."_https://www.theatlantic.com/ideas/archive/2021/04/how-pandemic-proof-world/618682/

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