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Slack / Private Message Drop, p.731 [SLACK_000945] · slack_pm:msg:07664

Page text: p.731 · original PDF

Date
2021-04-27 18:46
Type
chat message · slack
recipient
Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker
Kristian G. Andersen

Recipients on this medium are inferred from channel membership, not per-message addressing.

Could N be involved in transmissibility? Live link here: https://outbreak.info/compare-lineages?pango=B.1.1.7&pango=B.1.351&pango=P.1& pango=[...]gene=ORF7a&gene=ORF7b&gene=ORF8&gene=N&gene=ORF10&threshold=

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  1. 2021-04-27 18:44 Kristian G. Andersen open
    Are we starting to think maybe P681H/R could be a bad boy? Looking at the most recent variants, assuming B.1.617might plausibly be both more transmissible and escape some level of immunity, the latter comes down to L452R and the NTD, while the former may be linked to P681R (it doesn't have N501Y).P681H/R absent from both P.1 and B.1.351 (I'm getting increasingly more convinced 351 isn't more transmissible, but I'm less sure about P.1). [shared file(s): Screen Shot 2021-04-27 at 6.42.05 PM.png]
  2. 2021-04-27 18:45 Kristian G. Andersen open
    If looking outside the spike, what do we know about N? An interest pattern around position 203/204/205 here [shared file(s): Screen Shot 2021-04-27 at 6.39.40 PM.png]
  3. 2021-04-27 18:46 Kristian G. Andersen
    Could N be involved in transmissibility? Live link here: https://outbreak.info/compare-lineages?pango=B.1.1.7&pango=B.1.351&pango=P.1& pango=[...]gene=ORF7a&gene=ORF7b&gene=ORF8&gene=N&gene=ORF10&threshold=
  4. 2021-04-27 18:47 Kristian G. Andersen open
    Interferon?
  5. 2021-04-27 19:18 Edward C. Holmes open
    I had at chat with the genomics people here yesterday and they said that most of the people who are coming into our hotel quarantine system from India have B.1.1.7. Apparently 20% on one flight were infected.
  6. 2021-04-27 19:19 Robert F. Garry open
    "Could N be involved in transmissibility?" yes - I'll take a look.
  7. 2021-04-27 19:40 Kristian G. Andersen open
    20%... I think we see an example of what can happen if you give B.1.1.7 (and possibly 617) free reign. Pure devastation - the reports are terrifying.

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