Chat message

Slack / Private Message Drop, p.731 [SLACK_000945] · slack_pm:msg:07662

Date: 2021-04-27 18:44
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Are we starting to think maybe P681H/R could be a bad boy? Looking at the most recent variants, assuming B.1.617might plausibly be both more transmissible and escape some level of immunity, the latter comes down to L452R and the NTD, while the former may be linked to P681R (it doesn't have N501Y).P681H/R absent from both P.1 and B.1.351 (I'm getting increasingly more convinced 351 isn't more transmissible, but I'm less sure about P.1). [shared file(s): Screen Shot 2021-04-27 at 6.42.05 PM.png]

In context

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2021-04-27 18:44 Kristian G. Andersen

Are we starting to think maybe P681H/R could be a bad boy? Looking at the most recent variants, assuming B.1.617might plausibly be both more transmissible and escape some level of immunity, the latter comes down to L452R and the NTD, while the former may be linked to P681R (it doesn't have N501Y).P681H/R absent from both P.1 and B.1.351 (I'm getting increasingly more convinced 351 isn't more transmissible, but I'm less sure about P.1). [shared file(s): Screen Shot 2021-04-27 at 6.42.05 PM.png]
2021-04-27 18:45 Kristian G. Andersen open

If looking outside the spike, what do we know about N? An interest pattern around position 203/204/205 here [shared file(s): Screen Shot 2021-04-27 at 6.39.40 PM.png]
2021-04-27 18:46 Kristian G. Andersen open

Could N be involved in transmissibility? Live link here: https://outbreak.info/compare-lineages?pango=B.1.1.7&pango=B.1.351&pango=P.1& pango=[...]gene=ORF7a&gene=ORF7b&gene=ORF8&gene=N&gene=ORF10&threshold=
2021-04-27 18:47 Kristian G. Andersen open

Interferon?
2021-04-27 19:18 Edward C. Holmes open

I had at chat with the genomics people here yesterday and they said that most of the people who are coming into our hotel quarantine system from India have B.1.1.7. Apparently 20% on one flight were infected.

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