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Slack / Private Message Drop, p.701 [SLACK_000915] · slack_pm:msg:07352

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Looks very similar to the RBD dip

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-04-13 15:10 Edward C. Holmes open

Good point
2021-04-13 15:29 Andrew Rambaut open

I think clearly WIV were really shit at creating SC2
2021-04-13 15:30 Andrew Rambaut open

GX pango still not nearly as similar as RaTG13: [shared file(s): image.png]
2021-04-13 15:32 Andrew Rambaut open

Just noticed that dip in early ORF1a - don't know why I didn't notice that before.
2021-04-13 15:33 Andrew Rambaut

Looks very similar to the RBD dip
2021-04-13 16:06 Robert F. Garry open

interesting region at the amino acid level as well.
2021-04-13 16:17 Kristian G. Andersen open

Very interesting stuff! Might be worth looking at reversions - do we see more of those in the NTD vs the rest of the spike / genome?
2021-04-13 16:17 Andrew Rambaut open

I assume RmYN02 doesn't drop away like that.
2021-04-13 16:19 Andrew Rambaut open

@Kristian Andersen Actually they did some reversions and and mutants as will but but I didn't grab a screenshot so Ican't remember the details. I will see if he will send the slide deck or is going to be preprinting soon.