Slack / Private Message Drop — page 701

Just noticed that dip in early ORF1a - don't know why I didn't notice that before. [2021-04-13 15:33:12] [Andrew Rambaut] Looks very similar to the RBD dip [2021-04-13 16:06:03] [Robert Garry] interesting region at the amino acid level as well. [2021-04-13 16:17:06] [Kristian Andersen] Very interesting stuff! Might be worth looking at reversions - do we see more of those in the NTD vs the rest of the spike / genome? [2021-04-13 16:17:07] [Andrew Rambaut] [thread - ID: 2021-04-13 16:17:07] I assume RmYN02 doesn't drop away like that. [2021-04-13 16:19:13] [Andrew Rambaut] @Kristian Andersen Actually they did some reversions and and mutants as will but but I didn't grab a screenshot so I can't remember the details. I will see if he will send the slide deck or is going to be preprinting soon. [2021-04-13 16:20:51] [Kristian Andersen] [thread - ID: 2021-04-13 16:20:51] Cool beans! And I should add - we all need more afternoons of geeky genomics! [2021-04-13 18:31:04] [Robert Garry] [thread - ID: 2021-04-13 16:20:51] @Kristian Andersen Yeah - really cool - looking forward to the preprint! [2021-04-13 20:49:01] [Eddie Holmes] Just got this from Deep Throat in China "I hear that multiple groups has entered Yunnan, wiping every single butts of bats (other animals as well)". Well, they're looking... [2021-04-14 01:27:16] [Robert Garry] https://virological.org/t/spike-protein-mutations-in-novel-sars-cov-2-variants-of-concern-commonly-occur-in-or-near-i ndels/605 Speaking of "reversions" re @Andrew Rambaut geeky thread above. Tommy Lam - in our virological post - noted that passage of GX pangocov on Vero cells resulted in an insertion in Indel Region 2 - precisely at the H69/V70 deletion in B117. [2021-04-14 01:34:09] [Andrew Rambaut] Yes - Joe cited that post in his talk and used the same Indel Region notation - I just didn't capture that slide. [2021-04-14 07:25:45] [Robert Garry]