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Slack / Private Message Drop, p.631 [SLACK_000845] · slack_pm:msg:06611

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It would be multiple lineages going into animal reservoirs and then popping back out again.

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2021-03-25 10:06 Andrew Rambaut open

Bonkers: [shared file(s): image.png]
2021-03-25 10:13 Robert F. Garry open

no DouG?
2021-03-25 10:48 Kristian G. Andersen open

Just nuts. Simple question - why are we convinced this is _not_ happening in some animal reservoir?
2021-03-25 10:50 Andrew Rambaut open

Why would it?
2021-03-25 10:51 Andrew Rambaut

It would be multiple lineages going into animal reservoirs and then popping back out again.
2021-03-25 10:52 Andrew Rambaut open

Perhaps it is happening in HIV infected individuals?
2021-03-25 10:57 Robert F. Garry open

I agree - unlikely. However, better vaccinate Noodle and Turbo just in case.
2021-03-25 10:59 Robert F. Garry open

But yeah - untreated HIV infection seems like it would make a person a perfect incubator to generate variants.
2021-03-25 11:42 Kristian G. Andersen open

I agree that human infection (maybe HIV infected individuals / immunocompromised) makes the most sense, however, that new paper on VOCs being able to infect rodents... Could be a huge undiscovered reservoir hiding too- because we aren't really looking outside humans. But I agree - much less likely, although I think we should becareful not to dismiss the possibility.