Private channel session 1154
33 messages over 5h 14m, 2021-03-25 – 2021-03-25.
A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.
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Heard that WHO report will [likely] be published tomorrow, midday US time.
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In case people are interested in some light "science" entertainment. [shared file(s): [TODAY 4PM PST] IMM Seminar Series: Professor George F. Gao]
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This seems, well, like a lot of mutations. https://www.krisp.org.za/publications.php?pubid=330
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That's insanity - from three people. Spread of SC2 in populations with high levels of immunosuppression - better get those ppl vaccinated.
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HIV community?
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The uncontrolled experiment is happening as we speak.
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Bonkers: [shared file(s): image.png]
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no DouG?
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Just nuts. Simple question - why are we convinced this is _not_ happening in some animal reservoir?
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Why would it?
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It would be multiple lineages going into animal reservoirs and then popping back out again.
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Perhaps it is happening in HIV infected individuals?
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I agree - unlikely. However, better vaccinate Noodle and Turbo just in case.
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But yeah - untreated HIV infection seems like it would make a person a perfect incubator to generate variants.
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I agree that human infection (maybe HIV infected individuals / immunocompromised) makes the most sense, however, that new paper on VOCs being able to infect rodents... Could be a huge undiscovered reservoir hiding too- because we aren't really looking outside humans. But I agree - much less likely, although I think we should becareful not to dismiss the possibility.
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Should look for SC2 antibodies in pets of C19 households - it shouldn't be too hard to find C19 households with cats, dogs and even ferrets [ferrets are surprisingly popular]. Just contact some vets.
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60 minutes decided to follow up their good story on variants with a crap story on lab leaks [shared file(s): image.png]
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WTF!!!??? With Jamie - of all people? Really?
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Yes - this is shit - unlikely to have much if any real pushback in the 60min report I'm guessing - He'll be pushing the fact that the Chinese military is Shi's puppet master.
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They typically have good people on - how he is even remotely relevant to this discussion, I don't understand.
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Here's a much higher resolution map of the Huanan seafood market. [shared file(s): image.png]
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Now the update is that the WHO report is coming out next week.
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At least Metzl's missing the opportunity to bash the actual report on 60min.
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I think I can map the samples onto the map with a little help.
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Getting a translation on that map and Ct values would be great
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well maybe no ct values but we know which samples generated positive sequences - i guess of pcr products and which gave genomes at least partial by ngs. it's a pretty good surrogate. i'll try to get Shitao to help me before cobtoday.
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@Robert Garry more unforced errors - it's how you lose a tennis match as i understand it.
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There's clearly clustering of cases in some of the stalls - I'd like to know that those held raccoon dogs and/orcivets... Or pangolins. Or whatever.
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My guess is that's what Daszak's tiling project is trying to show along with Eddie's smoking raccoon dog pics. "Thirty-one of the 33 positive samples were collected from the western zone of the market, where booths of wildlife trading concentrated. The result suggests that the novel coronavirus outbreak is highly relevant to the trading of the wild animals, experts said. The successful isolation of the novel coronavirus further substantiates that the Huanan Seafood Wholesale Market contains a large quantity of the novel coronavirus (2019-nCoV), according to the experts."
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Ask George Gao when you get him on Zoom at 4 your time!
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Maybe get the Ct values too while you're at it :thinking_face:
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All we can do now is wait for the WHO report - that will change the debate. I doubt George will say much of interest.
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Zhang just told me that the Director of his institute in Shanghai just got the boot for protecting him last year. The Ministry of Health are keen for vengeance.