Slack / Private Message Drop — page 631

This seems, well, like a lot of mutations. https://www.krisp.org.za/publications.php?pubid=330 [2021-03-25 09:45:15] [Robert Garry] That's insanity - from three people. Spread of SC2 in populations with high levels of immunosuppression - better get those ppl vaccinated. [2021-03-25 09:49:45] [Kristian Andersen] HIV community? [2021-03-25 10:00:57] [Robert Garry] The uncontrolled experiment is happening as we speak. [2021-03-25 10:06:20] [Andrew Rambaut] Bonkers: [shared file(s): image.png] [2021-03-25 10:13:18] [Robert Garry] no DouG? [2021-03-25 10:48:21] [Kristian Andersen] Just nuts. Simple question - why are we convinced this is _not_ happening in some animal reservoir? [2021-03-25 10:50:56] [Andrew Rambaut] Why would it? [2021-03-25 10:51:39] [Andrew Rambaut] It would be multiple lineages going into animal reservoirs and then popping back out again. [2021-03-25 10:52:29] [Andrew Rambaut] Perhaps it is happening in HIV infected individuals? [2021-03-25 10:57:11] [Robert Garry] I agree - unlikely. However, better vaccinate Noodle and Turbo just in case. [2021-03-25 10:59:48] [Robert Garry] But yeah - untreated HIV infection seems like it would make a person a perfect incubator to generate variants. [2021-03-25 11:42:22] [Kristian Andersen] I agree that human infection (maybe HIV infected individuals / immunocompromised) makes the most sense, however, that new paper on VOCs being able to infect rodents... Could be a huge undiscovered reservoir hiding too - because we aren't really looking outside humans. But I agree - much less likely, although I think we should be careful not to dismiss the possibility.