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Slack / Private Message Drop, pp.609-610 [SLACK_000823] · slack_pm:msg:06377

Date: 2021-03-20 09:46
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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Also this tree, but I suspect that the same I just linked to, and yes, probably RdRp. Same IDs, so clearly the same. And clearly, they don't have the full genomes (because, well, bloody hard to do) [shared file(s):Ew35lxKU8AAbXdw.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-03-20 09:42 Kristian G. Andersen open

Andrew - since you have a keen eye. Do you know which 'mystery' sequences and viruses Jesse is talking about? I'm quite confused. I think maybe he means these? https://twitter.com/K_G_Andersen/status/1373310963680571397?s=20 Clearly they must be fragments they have managed to successfully sequence, as they mention in the Nature addendum - so absolutely no mystery. Am I missing something?
2021-03-20 09:43 Andrew Rambaut open

I was assuming it was those. Some RdRp PCR products I assume
2021-03-20 09:44 Robert F. Garry open

Good to be discussing these points ahead of a likely burst of reporting with the relaese of the WHO report! I already have several reporters promising to call.
2021-03-20 09:45 Kristian G. Andersen open

... and then this slide showing that they have managed to get some spike sequences too? Clearly very distant. [shared file(s): EvVevMrXcAA_GmP.jpeg]
2021-03-20 09:46 Kristian G. Andersen

Also this tree, but I suspect that the same I just linked to, and yes, probably RdRp. Same IDs, so clearly the same. And clearly, they don't have the full genomes (because, well, bloody hard to do) [shared file(s):Ew35lxKU8AAbXdw.png]
2021-03-20 09:50 Robert F. Garry open

@Andrew Rambaut points well taken re cross-reactivity - even the best seroassays are not 100% - the paper we referenced in PO1 and the one Daszak is talking about did look for cross-rxty with other covs. https://link.springer.com/article/10.1007/s12250-018-0012-7 cloned most of the known human covs and tested thoseas well as follow-up western blotting. my take is at least some sarbecovirus reactivity possible.
2021-03-20 10:01 Robert F. Garry open

...and the cdc paper - which i cant find now - showing seroreactivty to SC2 pre-pandemic was crap.
2021-03-20 10:07 Robert F. Garry open

More crap: https://undark.org/2021/03/18/utterly-plausible-lab-leak-hypothesis/
2021-03-20 10:14 Robert F. Garry open

Reality: Every one of the zoo's panthers are equipped with chips. The instant the animal left it's perimeter, alertswere sounded and a team was sent to capture it before it escaped the zoo, The zoo has large fence around itsperimeter as well.

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