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Slack / Private Message Drop, p.610 [SLACK_000824] · slack_pm:msg:06378

Date: 2021-03-20 09:50
Type: chat message · slack
mentioned: Andrew Rambaut
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry

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@Andrew Rambaut points well taken re cross-reactivity - even the best seroassays are not 100% - the paper we referenced in PO1 and the one Daszak is talking about did look for cross-rxty with other covs. https://link.springer.com/article/10.1007/s12250-018-0012-7 cloned most of the known human covs and tested thoseas well as follow-up western blotting. my take is at least some sarbecovirus reactivity possible.

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journal https://link.springer.com/article/10.1007/s12250-018-0012-7

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A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-03-20 09:43 Andrew Rambaut open

I was assuming it was those. Some RdRp PCR products I assume
2021-03-20 09:44 Robert F. Garry open

Good to be discussing these points ahead of a likely burst of reporting with the relaese of the WHO report! I already have several reporters promising to call.
2021-03-20 09:45 Kristian G. Andersen open

... and then this slide showing that they have managed to get some spike sequences too? Clearly very distant. [shared file(s): EvVevMrXcAA_GmP.jpeg]
2021-03-20 09:46 Kristian G. Andersen open

Also this tree, but I suspect that the same I just linked to, and yes, probably RdRp. Same IDs, so clearly the same. And clearly, they don't have the full genomes (because, well, bloody hard to do) [shared file(s):Ew35lxKU8AAbXdw.png]
2021-03-20 09:50 Robert F. Garry

@Andrew Rambaut points well taken re cross-reactivity - even the best seroassays are not 100% - the paper we referenced in PO1 and the one Daszak is talking about did look for cross-rxty with other covs. https://link.springer.com/article/10.1007/s12250-018-0012-7 cloned most of the known human covs and tested thoseas well as follow-up western blotting. my take is at least some sarbecovirus reactivity possible.
2021-03-20 10:01 Robert F. Garry open

...and the cdc paper - which i cant find now - showing seroreactivty to SC2 pre-pandemic was crap.
2021-03-20 10:07 Robert F. Garry open

More crap: https://undark.org/2021/03/18/utterly-plausible-lab-leak-hypothesis/
2021-03-20 10:14 Robert F. Garry open

Reality: Every one of the zoo's panthers are equipped with chips. The instant the animal left it's perimeter, alertswere sounded and a team was sent to capture it before it escaped the zoo, The zoo has large fence around itsperimeter as well.
2021-03-20 10:29 Robert F. Garry open

https://www.sciencemag.org/news/2021/03/major-coronavirus-variant-found-pets-first-time:black_cat::cat2::dog2: ohmy.

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