A single line often inverts meaning once you see what it
answers, so neighbouring messages are always shown.
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Then there is the whole lineage A and B = the animals in the Huanan market are lineage B, so how did lineage A get started? The NEJM paper says other case werelinked to other markets, but which ones and which were sequenced Idon't know,.
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My read as well -on Marion.
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Yes, Marion is cautious so they must have something. Hope they release soon. I may have told you but I also heard that they had discounted the Dec 1 case and the earliest known one is now Dec 8. I also think I heard that while this patient had no link to the market his parents had some sort of link to another live animal market. Not sure is this issomething or not.
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Dec 8 is consistent with the graph from the CCDC NEJM paper.
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2021-03-15 13:46
Robert F. Garry
Lots of questions for Kristian: [shared file(s): image.png]
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Pathetic
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I think there's _a lot_ of early unsampled diversity, which can help explain the A vs B split. Much focus turned to the Huanan market, where super spreading might have occurred, so we end up having very biased sampling early on.
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That seems right. But is the diversity in unsampled humans, unsampled animals or perhaps both. Only A and B lineages made it through the bottleneck.
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Another way to ask the questions: B came from A as Andrew said in the NatMicro paper. But did the split happen inan animal or after the human to animal transfer? Maybe doesn't really matter.