Chat message

Slack / Private Message Drop, p.566 [SLACK_000780] · slack_pm:msg:05915

Date: 2021-03-04 13:27
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen
Topics: Vaccines

Recipients on this medium are inferred from channel membership, not per-message addressing.

Also, one very interesting finding - although it's n=1. They had somebody infected by non-B.1.351 _but_ with a virus that had the E484K mutation. The serum from that patient absolutely knocked it out of the park when it came to neuttiers against both B.1.351 and non-B.1.351 - so much so, they had to exclude the individual from most analyses. Ifthis holds up, we might have a winner for near-perfect vaccine antigen - spike + E484K, 2P, and dFCS. That'd becool.

Extracted statements

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Statement	Grade	Attribution	Stance
Ifthis holds up, we might have a winner for near-perfect vaccine antigen - spike + E484K, 2P, and dFCS.	needs context	uncertain explicit hedge	asserts

Statement

Grade

Attribution

Stance

Ifthis holds up, we might have a winner for near-perfect vaccine antigen - spike + E484K, 2P, and dFCS.

needs context

uncertain explicit hedge

asserts

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-03-04 12:39 Edward C. Holmes open

This one does not look very good and talks about enhanced fitness. But I don't have time to look at it now as I haveto do another talk.
2021-03-04 12:55 Kristian G. Andersen open

I see it Eddie - will take a look. We have a few very recent genomes that smell like recombination to me as well - I'm pretty convinced recombination happens quite frequently, so (as discussed before), I'm not surprised. That said, need proper evidence.
2021-03-04 12:59 Kristian G. Andersen open

Yeah, junk. "The VOCs have a lot of mutations so they must be recombinants"....
2021-03-04 13:25 Kristian G. Andersen open

*Key* paper from South Africa here - people infected with B.1.351 fully neutralize B.1.351 viruses AND neutralizenon-B.1.351 viruses pretty well. https://www.medrxiv.org/content/10.1101/2021.01.26.21250224v2
2021-03-04 13:27 Kristian G. Andersen

Also, one very interesting finding - although it's n=1. They had somebody infected by non-B.1.351 _but_ with a virus that had the E484K mutation. The serum from that patient absolutely knocked it out of the park when it came to neuttiers against both B.1.351 and non-B.1.351 - so much so, they had to exclude the individual from most analyses. Ifthis holds up, we might have a winner for near-perfect vaccine antigen - spike + E484K, 2P, and dFCS. That'd becool.
2021-03-04 14:19 Edward C. Holmes open

I finally looked at this carefully. Did you see the BEAST analysis? TempEST found no temporal structure so they went ahead and used a strick clock anyway. On a 440 nt region. [shared file(s): Latrinne.NatComm20.pdf]
2021-03-04 15:13 Kristian G. Andersen open

You know, no point in having data get in the way of a good story.

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