Private channel session 1054

13 messages over 4h 7m, 2021-03-04 – 2021-03-04.

A “conversation” here is an activity session — a run of messages with under 60 minutes of silence inside it. The channel had no native conversation boundaries.

2021-03-04 11:06 Edward C. Holmes open PDF p.565

Bruno Canard is credible. I'm not sure why he goes for this. But it's a really weak list. REALLY weak. GenerallyC-listers. Interesting to see Claverie on board, although he is routinely full of shit.I spoke to Peter Daszak last week and he said he was just finishing his part of the report. My Wuhan holiday snapsare in their somewhere.
2021-03-04 11:26 Kristian G. Andersen open PDF p.565

OK article from Betsy - and great quote from you Bob!
2021-03-04 11:34 Edward C. Holmes open PDF p.566

The Bob's Bollocks!
2021-03-04 11:37 Robert F. Garry open PDF p.566

Oh yes - but perhaps a bit of a missed opportunity for more Bullocks on FoxBusiness....Might have been fun but ....
2021-03-04 12:17 Edward C. Holmes open PDF p.566

@Kristian Andersen There's a recombination paper in the bioRxiv queue that would be good if you took a look at. Looks like garbage to me.
2021-03-04 12:35 Andrew Rambaut open PDF p.566

I found some solid examples of recombination with B.1.1.7. No surprises but pretty clear with multiple genomes sequenced in different labs.
2021-03-04 12:39 Edward C. Holmes open PDF p.566

This one does not look very good and talks about enhanced fitness. But I don't have time to look at it now as I haveto do another talk.
2021-03-04 12:55 Kristian G. Andersen open PDF p.566

I see it Eddie - will take a look. We have a few very recent genomes that smell like recombination to me as well - I'm pretty convinced recombination happens quite frequently, so (as discussed before), I'm not surprised. That said, need proper evidence.
2021-03-04 12:59 Kristian G. Andersen open PDF p.566

Yeah, junk. "The VOCs have a lot of mutations so they must be recombinants"....
2021-03-04 13:25 Kristian G. Andersen open PDF p.566

*Key* paper from South Africa here - people infected with B.1.351 fully neutralize B.1.351 viruses AND neutralizenon-B.1.351 viruses pretty well. https://www.medrxiv.org/content/10.1101/2021.01.26.21250224v2
2021-03-04 13:27 Kristian G. Andersen open PDF p.566

Also, one very interesting finding - although it's n=1. They had somebody infected by non-B.1.351 _but_ with a virus that had the E484K mutation. The serum from that patient absolutely knocked it out of the park when it came to neuttiers against both B.1.351 and non-B.1.351 - so much so, they had to exclude the individual from most analyses. Ifthis holds up, we might have a winner for near-perfect vaccine antigen - spike + E484K, 2P, and dFCS. That'd becool.
2021-03-04 14:19 Edward C. Holmes open PDF p.566

I finally looked at this carefully. Did you see the BEAST analysis? TempEST found no temporal structure so they went ahead and used a strick clock anyway. On a 440 nt region. [shared file(s): Latrinne.NatComm20.pdf]
2021-03-04 15:13 Kristian G. Andersen open PDF p.567

You know, no point in having data get in the way of a good story.