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Slack / Private Message Drop, p.527 [SLACK_000741] · slack_pm:msg:05496

Page text: p.527 · original PDF

Date
2021-02-19 14:38
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry

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Exactly!

In context

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  1. 2021-02-19 14:17 Robert F. Garry open
    Yeah -that it... It's DouG's world but his naughty polymerase girlfriend PearL may be causing a lot of disruption onher own.
  2. 2021-02-19 14:26 Kristian G. Andersen open
    You know - none of these spike mutations may make SARS-CoV-2 more transmissible...
  3. 2021-02-19 14:30 Robert F. Garry open
    You could be right - Thinking back and Bob C and Tom Geisbert will know better, but I think that all of the mutations that make LASV replicate in guinea pigs are in polymerase.
  4. 2021-02-19 14:34 Kristian G. Andersen open
    I believe in flu, the polymerase is key too.
  5. 2021-02-19 14:38 Robert F. Garry
    Exactly!
  6. 2021-02-19 14:39 Robert F. Garry open
    Although occasionally a little FCS can get involved in the fun.
  7. 2021-02-19 14:45 Andrew Rambaut open
    I heard from a confidential source that in macaque infections P323L (Phil) came up in 10/10 monkeys.
  8. 2021-02-19 14:46 Andrew Rambaut open
    And yes Phil is strongly linked with Doug but came up first (in January).
  9. 2021-02-19 14:47 Andrew Rambaut open
    I think it is probably the first major human adaptation

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