Chat message

Slack / Private Message Drop, p.522 [SLACK_000736] · slack_pm:msg:05441

Date: 2021-02-17 14:31
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Edward C. Holmes
speaker: Andrew Rambaut

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Basically they have lots of recurrent mutations (I say, they have - I mean they have found in other people's data). Most are clearly just homoplasies being brought up by epistatic effects. Their only argument is that they are rare globally.

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2021-02-17 14:19 Andrew Rambaut open

Oli, Nick and I were talking to Korber about your recombination problem in California
2021-02-17 14:20 Kristian G. Andersen open

She would give zero information - what does she have?
2021-02-17 14:28 Andrew Rambaut open

Yup.
2021-02-17 14:29 Andrew Rambaut open

She told us how you find recombination
2021-02-17 14:31 Andrew Rambaut

Basically they have lots of recurrent mutations (I say, they have - I mean they have found in other people's data). Most are clearly just homoplasies being brought up by epistatic effects. Their only argument is that they are rare globally.
2021-02-17 14:33 Andrew Rambaut open

She showed one picture that looked like a convincing case because it had 2 parents and good tracts of recombination (i.e., the entire spike) but was either a lab artifact, or a coinfected individual with a messed upconsensus or an actual unusual recombination. None of it matters though - clearly recombination is massively important to within host evolution and vanishingly unimportant to population evolution except in so far as the first leads to the second
2021-02-17 14:34 Edward C. Holmes open

As for Laura Boykin - idiotic nonsense. I'm not sure how B.1.1.7 counts as white.
2021-02-17 14:35 Andrew Rambaut open

I think she is confused.
2021-02-17 14:35 Edward C. Holmes open

@Robert Garry I've gone through the text again Bob - looks good. I'm happy with the cuts.

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