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Slack / Private Message Drop, p.522 [SLACK_000736] · slack_pm:msg:05438

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She would give zero information - what does she have?

In context

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2021-02-17 14:19 Andrew Rambaut open

(Korber, I mean)
2021-02-17 14:19 Robert F. Garry open

Laura seems nice. Good sense of humor. Grounded. Knows what's important. Doesn't sweat the small stuff. Focused.
2021-02-17 14:19 Andrew Rambaut open

That totally sums her up.
2021-02-17 14:19 Andrew Rambaut open

Oli, Nick and I were talking to Korber about your recombination problem in California
2021-02-17 14:20 Kristian G. Andersen

She would give zero information - what does she have?
2021-02-17 14:28 Andrew Rambaut open

Yup.
2021-02-17 14:29 Andrew Rambaut open

She told us how you find recombination
2021-02-17 14:31 Andrew Rambaut open

Basically they have lots of recurrent mutations (I say, they have - I mean they have found in other people's data). Most are clearly just homoplasies being brought up by epistatic effects. Their only argument is that they are rare globally.
2021-02-17 14:33 Andrew Rambaut open

She showed one picture that looked like a convincing case because it had 2 parents and good tracts of recombination (i.e., the entire spike) but was either a lab artifact, or a coinfected individual with a messed upconsensus or an actual unusual recombination. None of it matters though - clearly recombination is massively important to within host evolution and vanishingly unimportant to population evolution except in so far as the first leads to the second