Slack / Private Message Drop — page 522

[2021-02-17 14:15:45] [Kristian Andersen] I don't know her - but I was just on a three hour meeting with Bette Korber so I can't take any more ranting today. :firecracker: [2021-02-17 14:17:57] [Kristian Andersen] I get the sense Aine's got this one down though.:clap: [shared file(s): Screen Shot 2021-02-17 at 2.17.23 PM.png] [2021-02-17 14:18:24] [Andrew Rambaut] Ooh yours must have been the call she had to leave mine to go to. [2021-02-17 14:19:02] [Andrew Rambaut] (Korber, I mean) [2021-02-17 14:19:16] [Robert Garry] Laura seems nice. Good sense of humor. Grounded. Knows what's important. Doesn't sweat the small stuff. Focused. [2021-02-17 14:19:32] [Andrew Rambaut] That totally sums her up. [2021-02-17 14:19:49] [Andrew Rambaut] Oli, Nick and I were talking to Korber about your recombination problem in California [2021-02-17 14:20:58] [Kristian Andersen] She would give zero information - what does she have? [2021-02-17 14:28:55] [Andrew Rambaut] Yup. [2021-02-17 14:29:07] [Andrew Rambaut] She told us how you find recombination [2021-02-17 14:31:09] [Andrew Rambaut] Basically they have lots of recurrent mutations (I say, they have - I mean they have found in other people's data). Most are clearly just homoplasies being brought up by epistatic effects. Their only argument is that they are rare globally. [2021-02-17 14:33:35] [Andrew Rambaut] [thread - ID: 2021-02-17 14:33:35] She showed one picture that looked like a convincing case because it had 2 parents and good tracts of recombination (i.e., the entire spike) but was either a lab artifact, or a coinfected individual with a messed up consensus or an actual unusual recombination. None of it matters though - clearly recombination is massively important to within host evolution and vanishingly unimportant to population evolution except in so far as the first