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Slack / Private Message Drop, p.477 [SLACK_000691] · slack_pm:msg:04959

Page text: p.477 · original PDF

Date
2021-02-03 14:08
Type
chat message · slack
recipient
Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker
Edward C. Holmes

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Q2. Is there any decent evidence of selection outside of the spike?

In context

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  1. 2021-02-03 12:35 Edward C. Holmes open
    Fair point. I doubt if the 3 hours the WHO spent at WIV yesterday is going to appease many people. Looks like they are on a well planned sightseeing tour of Wuhan. I'll have a look at the Google doc when you are done Bob
  2. 2021-02-03 13:17 Edward C. Holmes open
    I may have missed this because I can't keep up. In that cast of character mutations how many are true 'immune escape' mutations in that they enable to reinfection of hosts, how many emerged in humans with some sort of partial immune response (e.g. chronic infection), and how many are compensatory/epistatic for other mutations. So, isNellY permissive for EriK? Or is it all of the above?
  3. 2021-02-03 13:21 Kristian G. Andersen open
    Leif, Karen, and Erik most concerning in that regard - probably...
  4. 2021-02-03 13:21 Edward C. Holmes open
    Decent evidence of reinfection?
  5. 2021-02-03 14:08 Edward C. Holmes
    Q2. Is there any decent evidence of selection outside of the spike?
  6. 2021-02-03 15:04 Andrew Rambaut open
    L18F came up secondarily in both RSA and UK
  7. 2021-02-03 15:04 Andrew Rambaut open
    On the other hand the deletion in nsp6 is in all 3 variants
  8. 2021-02-03 15:06 Edward C. Holmes open
    :+1:

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