Chat message

Slack / Private Message Drop, p.477 [SLACK_000691] · slack_pm:msg:04956

Date: 2021-02-03 13:17
Type: chat message · slack
recipient: Kristian G. Andersen, Robert F. Garry, Andrew Rambaut
speaker: Edward C. Holmes

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I may have missed this because I can't keep up. In that cast of character mutations how many are true 'immune escape' mutations in that they enable to reinfection of hosts, how many emerged in humans with some sort of partial immune response (e.g. chronic infection), and how many are compensatory/epistatic for other mutations. So, isNellY permissive for EriK? Or is it all of the above?

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-02-03 12:18 Kristian G. Andersen open

True. More importantly though, they're also the ones that will help this shit hole country get out of this mess. Then again, I guess we should require that, since they created the virus.
2021-02-03 12:24 Edward C. Holmes open

There's no point debating Fox with science.
2021-02-03 12:29 Robert F. Garry open

Unfortunately - and give Alina, Relman and a slew of others of the ilk "credit" where it's due- the left is alsoembracing the crazy. I've *completely reworked* the commentary re the new Bat CoVs and will update the google doc later today. THe version up there is way out of date.
2021-02-03 12:35 Edward C. Holmes open

Fair point. I doubt if the 3 hours the WHO spent at WIV yesterday is going to appease many people. Looks like they are on a well planned sightseeing tour of Wuhan. I'll have a look at the Google doc when you are done Bob
2021-02-03 13:17 Edward C. Holmes

I may have missed this because I can't keep up. In that cast of character mutations how many are true 'immune escape' mutations in that they enable to reinfection of hosts, how many emerged in humans with some sort of partial immune response (e.g. chronic infection), and how many are compensatory/epistatic for other mutations. So, isNellY permissive for EriK? Or is it all of the above?
2021-02-03 13:21 Kristian G. Andersen open

Leif, Karen, and Erik most concerning in that regard - probably...
2021-02-03 13:21 Edward C. Holmes open

Decent evidence of reinfection?
2021-02-03 14:08 Edward C. Holmes open

Q2. Is there any decent evidence of selection outside of the spike?
2021-02-03 15:04 Andrew Rambaut open

L18F came up secondarily in both RSA and UK

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