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Slack / Private Message Drop, p.472 [SLACK_000686] · slack_pm:msg:04903

Date: 2021-02-01 14:30
Type: chat message · slack
recipient: Robert F. Garry, Edward C. Holmes, Andrew Rambaut
speaker: Kristian G. Andersen

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@Kristian Andersen OK - might just be founder on our end. I just don't understand why additional mutations that get added to B.1.1.7 continue to primarily be non-synonymous....

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2021-02-01 14:21 Edward C. Holmes open

Thanks for doing that Bob. We did notice the similarity between HA379 and GD pango in parts of the sequence. Good point about HA321, HA363 and HA442. I'll check that with Weifeng. Attached is a tree with the species marked. [shared file(s): Fig_BetaV3.2_RdRp_tidy_AIv1.pdf]
2021-02-01 14:28 Andrew Rambaut open

@Kristian Andersen Seem to have 52 in a simple search.
2021-02-01 14:30 Kristian G. Andersen

@Kristian Andersen OK - might just be founder on our end. I just don't understand why additional mutations that get added to B.1.1.7 continue to primarily be non-synonymous....
2021-02-01 14:34 Andrew Rambaut open

@Kristian Andersen Actually 25 in England
2021-02-01 14:48 Andrew Rambaut open

@Kristian Andersen There may be a couple of independent origins of K1191N here (because this is only B.1.1.7 with K1191N) but looks like a founder to the US from UK. [shared file(s): K1191N.tree.png]
2021-02-01 14:49 Andrew Rambaut open

No you can't have your own variant. Their ours.
2021-02-01 14:50 Kristian G. Andersen open

@Kristian Andersen OK, thanks - makes sense since we see them in almost all (all?) Florida genomes, so I think itjust hitched a ride across the ocean. At least you didn't give us Eeek - yet... I suspect we'll see that fucker pop up byhimself here too.

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