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Slack / Private Message Drop, p.469 [SLACK_000683] · slack_pm:msg:04871

Recipients on this medium are inferred from channel membership, not per-message addressing.

I extracted the ORF and aligned in AA space - all come out with LLA deleted.

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-31 15:27 Andrew Rambaut open

shared file(s): image.png
2021-01-31 15:29 Andrew Rambaut open

Actually in nucleotides it could be one base further towards 3'
2021-01-31 15:30 Andrew Rambaut open

Definitely deletes 2 Ls and an A but could be LLA or LAL.
2021-01-31 15:32 Robert F. Garry open

Oh my...can we look at the del in the Tulane patient as a tie-breaker?
2021-01-31 15:34 Kristian G. Andersen

I extracted the ORF and aligned in AA space - all come out with LLA deleted.
2021-01-31 15:36 Andrew Rambaut open

But you could delete LAL and get the same amino acid sequence
2021-01-31 15:36 Robert F. Garry open

The whole region is subject to various deletions in some other immune compromised patients.
2021-01-31 15:37 Kristian G. Andersen open

I'll just accept I don't understand sequences... :wink:
2021-01-31 15:37 Andrew Rambaut open

Always look at the nucleotide sequences, man.