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Slack / Private Message Drop, p.453 [SLACK_000667] · slack_pm:msg:04700

Date: 2021-01-26 08:15
Type: chat message · slack
recipient: Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker: Robert F. Garry
Topics: Furin cleavage site and molecular features

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Here's that nucleotide alignment of spike at 30,000 feet - from the ATG to the FCS- not the mess I thought it wouldbe - you can clearly see the indels. To Kristian's point - the RBD actually aligns pretty well. [shared file(s): image.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-26 07:54 Kristian G. Andersen open

That'd be fun! I do have _some_ respect for Quay though - he noticed the early ENA samples - still not explained.
2021-01-26 08:11 Andrew Rambaut open

Cambodian bat genomes - just the variable loop: [shared file(s): image.png]
2021-01-26 08:11 Andrew Rambaut open

Rooted by other pangolins
2021-01-26 08:12 Kristian G. Andersen open

Just a matter of time before we see a near-perfect match to the RBD in bats,
2021-01-26 08:15 Robert F. Garry

Here's that nucleotide alignment of spike at 30,000 feet - from the ATG to the FCS- not the mess I thought it wouldbe - you can clearly see the indels. To Kristian's point - the RBD actually aligns pretty well. [shared file(s): image.png]
2021-01-26 08:23 Robert F. Garry open

And a bit of S2 - highly conserved at the amino acid level - but you can clearly see many instances of the ** ** **pattern, with the mismatches being the "wobble" base in the triplet. Designed by nature not a supervillain. [shared file(s): image.png]
2021-01-26 08:48 Andrew Rambaut open

Cara is trying again to get me to come to China: [shared file(s): image.png]
2021-01-26 08:48 Andrew Rambaut open

This time she has a name for the organisation.
2021-01-26 08:49 Andrew Rambaut open

If you look up "North American Foundation for Science and Technology" you get this very convincing website: https://www.northamericanfoundationforscienceandtechnology.com

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