Slack / Private Message Drop — page 453

[2021-01-26 07:46:48] [Andrew Rambaut] Enjoy - all 191 pages of it... [shared file(s): 2021-01-26_SQuay_Bayesian Analysis of SARS-CoV-2.pdf] [2021-01-26 07:47:12] [Andrew Rambaut] How do these people have so much time on their hands? [2021-01-26 07:47:28] [Kristian Andersen] Just saw it... I have no idea - I guess it's all they do? [2021-01-26 07:47:41] [Andrew Rambaut] I like the pacman logo though [2021-01-26 07:50:06] [Kristian Andersen] I should point out that Trevor was / is working on a Bayesian framework for this as well. Picking priors is a little sketchy... [2021-01-26 07:50:57] [Andrew Rambaut] We should reply to tell him that. Perhaps they could collaborate [2021-01-26 07:54:39] [Kristian Andersen] That'd be fun! I do have _some_ respect for Quay though - he noticed the early ENA samples - still not explained. [2021-01-26 08:11:40] [Andrew Rambaut] Cambodian bat genomes - just the variable loop: [shared file(s): image.png] [2021-01-26 08:11:58] [Andrew Rambaut] Rooted by other pangolins [2021-01-26 08:12:58] [Kristian Andersen] Just a matter of time before we see a near-perfect match to the RBD in bats, [2021-01-26 08:15:28] [Robert Garry] Here's that nucleotide alignment of spike at 30,000 feet - from the ATG to the FCS- not the mess I thought it would be - you can clearly see the indels. To Kristian's point - the RBD actually aligns pretty well. [shared file(s): image.png] [2021-01-26 08:23:36] [Robert Garry] And a bit of S2 - highly conserved at the amino acid level - but you can clearly see many instances of the ** ** ** pattern, with the mismatches being the "wobble" base in the triplet. Designed by nature not a supervillain. [shared file(s): image.png] [2021-01-26 08:48:18]