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Slack / Private Message Drop, p.453 [SLACK_000667] · slack_pm:msg:04697

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Cambodian bat genomes - just the variable loop: [shared file(s): image.png]

In context

A single line often inverts meaning once you see what it answers, so neighbouring messages are always shown.

2021-01-26 07:47 Andrew Rambaut open

I like the pacman logo though
2021-01-26 07:50 Kristian G. Andersen open

I should point out that Trevor was / is working on a Bayesian framework for this as well. Picking priors is a littlesketchy...
2021-01-26 07:50 Andrew Rambaut open

We should reply to tell him that. Perhaps they could collaborate
2021-01-26 07:54 Kristian G. Andersen open

That'd be fun! I do have _some_ respect for Quay though - he noticed the early ENA samples - still not explained.
2021-01-26 08:11 Andrew Rambaut

Cambodian bat genomes - just the variable loop: [shared file(s): image.png]
2021-01-26 08:11 Andrew Rambaut open

Rooted by other pangolins
2021-01-26 08:12 Kristian G. Andersen open

Just a matter of time before we see a near-perfect match to the RBD in bats,
2021-01-26 08:15 Robert F. Garry open

Here's that nucleotide alignment of spike at 30,000 feet - from the ATG to the FCS- not the mess I thought it wouldbe - you can clearly see the indels. To Kristian's point - the RBD actually aligns pretty well. [shared file(s): image.png]
2021-01-26 08:23 Robert F. Garry open

And a bit of S2 - highly conserved at the amino acid level - but you can clearly see many instances of the ** ** **pattern, with the mismatches being the "wobble" base in the triplet. Designed by nature not a supervillain. [shared file(s): image.png]