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Slack / Private Message Drop, p.449 [SLACK_000663] · slack_pm:msg:04651

Page text: p.449 · original PDF

Date
2021-01-25 12:14
Type
chat message · slack
recipient
Kristian G. Andersen, Edward C. Holmes, Andrew Rambaut
speaker
Robert F. Garry
Topics
Natural origin / zoonotic spillover

Recipients on this medium are inferred from channel membership, not per-message addressing.

That would be great - have some ideas gelling for an "opinion" piece for Virological. Something along the lines of:New sequences disprove conspiracy theories based on contrived origins of bat coronavirus RatG13 and pangolin coronaviruses.

In context

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  1. 2021-01-25 11:46 Robert F. Garry open
    Cambobatcov spike pretty interesting - it has the E484 and 5/6 of the GD Pango/SC2 RBD residues we highlighted in PO1. Add to that the furin landing site QTQTN that it shares with PangoGD CoV and RatG13. [shared file(s): image.png]
  2. 2021-01-25 11:55 Robert F. Garry open
    So bottom line a new bat virus that confirms the authenticity of GD pangocov.
  3. 2021-01-25 12:09 Edward C. Holmes open
    Brilliant work Bob! The Cambobatcov paper should be online soon I believe
  4. 2021-01-25 12:14 Robert F. Garry
    That would be great - have some ideas gelling for an "opinion" piece for Virological. Something along the lines of:New sequences disprove conspiracy theories based on contrived origins of bat coronavirus RatG13 and pangolin coronaviruses.
  5. 2021-01-25 12:44 Edward C. Holmes open
    Love it! Looking forward to having a rant on Twitter
  6. 2021-01-25 12:59 Andrew Rambaut open
    Amazing. So the Cambobat has the RBD that RaTG13 lost through recombination and is slightly closer than the GD pango by the looks?
  7. 2021-01-25 13:01 Andrew Rambaut open
    On closer inspection maybe it isn't quite that simple but hey - really interesting
  8. 2021-01-25 13:06 Robert F. Garry open
    Yes, but I think your first approximation is pretty spot on - taking a look at the nucleotide alignment - maybe a case where the protein alignment gives a slightly different picture than the nucleotide alignment. - as ProfBill often saysyou can see the "wobble" codons. That's natural evolution of course not nonsense like the WIV supervillains creatinga fake set of SRA data to cover up their GOF/bioweapons program.

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